The hallmark of Hashimoto’s thyroiditis is hypothyroidism. A positive history of autoimmune diseases and certain drug use are suggestive of Hashimoto’s thyroiditis. The most common symptoms of Hashimoto’s thyroiditis include fatigue, constipation, and cold intolerance.

Patients with Hashimoto’s thyroiditis usually have the history of other autoimmune diseases and family history of autoimmune diseases. Occasionally, there might be a history of certain drug use like interferon-alpha and monoclonal antibodies.

In many cases, Hashimoto’s thyroiditis usually results in hypothyroidism, although, in its acute phase, it can cause a transient hyperthyroidism thyrotoxic state known as hashitoxicosis. Hypothyroidism resulting from Hashimoto’s thyroiditis can cause these symptoms:^{[1][2]_American_Thyroid_Association-3|[3]}

• Fatigue
• Weight gain
• Constipation
• Cold intolerance
• Dry skin
• Depression
• Muscle aches
• Reduced exercise tolerance
• Menorrhagia or metrorrhagia

There are several organs involved in the hypothyroidism associated with Hashimoto’s thyroiditis. The manifestation of Hashimoto’s thyroiditis is variable as a result of the extensive involvement of multiple organs. The organ-based manifestation are as follows:

​