Patients with hemophilia can present with a history of excessive bleeding after minor injuries or spontaneous bleeding. They can also report family history of hemophilia. Hemophilia when mild, can be asymptomatic. Common symptoms, when present, include epistaxis, oral mucosal bleeding, joint pain and swelling, lethargy and fatigue, excessive bleeding after dental procedures, prolonged bleeding after circumcision and muscle hematoma after vaccination.

Patients with hemophilia may have a positive history of:

• Male family members with uncontrollable bleeding episodes^[1][2]
• Easy bruising^[3]
• Prolonged excessive bleeds following surgery or trauma^[3]
• Patients with hemarthroses can present with:

• Joint motion limitation^[4]
• Pain, and discomfort^[4][5]
• Cutaneous warmth^[5]
• Joint swelling^[5]

• Patients with intracranial bleeds can present with a history of:

• Seizures^[6]
• Headache^[7]
• Double vision
• Vomiting^[7]
• Unconciousness^[7]

Central nervous system

• Seizures^[8][6]
• Weakness^[8][9][10]
• Hypothermia^[8]
• Pupillary changes^[8]
• Vomiting^[7]
• Unconciousness^[7][9]

Musculoskeletal

• Joint pain and discomfort^{[4][5][11][12]}
• Joint motion limitation^[12]
• Muscle weakness^[11]
• Muscle swelling, pain, and tenderness^{[13][14][15][16]}
• Cutaneous warmth^[5]

Gastrointestinal

• Bloody vomiting^[17][18]
• Bloody stool^[18]

Genitourinary

• Post-circumcision bleeding^[19][1]
• Dark colored urine^[20]
• Blood in urine^[20][21][22]

Other

• Nose and gum bleeds^[23][24]
• Excessive menstrual bleeding^[24]