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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Hepatocellular carcinoma causes

Introduction

Overview

Overview

Common causes of hepatocellular carcinoma include hepatitis B, hepatitis C, alcoholic liver cirrhosis, hemochromatosis, and hepatic porphyrias. Other causes include non alcholic fatty liver disease, non-alchoholic steatohepatitis, and metabolic disorders as diabetes mellitus type two and obesity.

Common Causes

Common Causes

Common causes of hepatocellular carcinoma include the following:[1][2][3][4][5][6][7]

Less common causes

Less common causes

Less common causes of hepatocellular carcinoma include the following:[8][9][10]

Drugs

Drugs

The carcinogenic drugs for hepatocellular carcinoma are:

References

References

  1. ↑ Jiang, Kun; Centeno, Barbara A. (2018). “Primary Liver Cancers, Part 2”. Cancer Control. 25 (1): 107327481774465. doi:10.1177/1073274817744658. ISSN 1073-2748.
  2. ↑ Said, Adnan; Ghufran, Aiman (2017). “Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma”. World Journal of Clinical Oncology. 8 (6): 429–436. doi:10.5306/wjco.v8.i6.429. ISSN 2218-4333.
  3. ↑ Erkekoglu P, Oral D, Chao MW, Kocer-Gumusel B (2017). “Hepatocellular Carcinoma and Possible Chemical and Biological Causes: A Review”. J. Environ. Pathol. Toxicol. Oncol. 36 (2): 171–190. doi:10.1615/JEnvironPatholToxicolOncol.2017020927. PMID 29199597.
  4. ↑ Fu, Jing; Wang, Hongyang (2018). “Precision diagnosis and treatment of liver cancer in China”. Cancer Letters. 412: 283–288. doi:10.1016/j.canlet.2017.10.008. ISSN 0304-3835.
  5. ↑ Fujiwara N, Friedman SL, Goossens N, Hoshida Y (2017). “Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine”. J. Hepatol. doi:10.1016/j.jhep.2017.09.016. PMID 28989095.
  6. ↑ Parkin, Donald Maxwell (2006). “The global health burden of infection-associated cancers in the year 2002”. International Journal of Cancer. 118 (12): 3030–3044. doi:10.1002/ijc.21731. ISSN 0020-7136.
  7. ↑ Shi, J; Zhu, L; Liu, S; Xie, W-f (2005). “A meta-analysis of case–control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China”. British Journal of Cancer. 92 (3): 607–612. doi:10.1038/sj.bjc.6602333. ISSN 0007-0920.
  8. ↑ Agosti, Pasquale; Sabbà, Carlo; Mazzocca, Antonio (2018). “Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment”. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 1864 (2): 607–617. doi:10.1016/j.bbadis.2017.11.026. ISSN 0925-4439.
  9. ↑ Gerbes A, Zoulim F, Tilg H, Dufour JF, Bruix J, Paradis V, Salem R, Peck-Radosavljevic M, Galle PR, Greten TF, Nault JC, Avila MA (2018). “Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma”. Gut. 67 (2): 380–388. doi:10.1136/gutjnl-2017-315068. PMID 29150490.
  10. ↑ Didi-Kouko Coulibaly J, Yeboua M, Kouassi Mbengue A, Kouadio EA, Anzouan-Kacou Kissi H, Binan AY, Lohoues Kouacou MJ, Attia A, N’Drin DY, Toutou T, Adoubi I, Pineau P (2017). “Evolution of hepatocellular carcinoma epidemiology in Côte d’Ivoire”. Bull Cancer. 104 (11): 937–945. doi:10.1016/j.bulcan.2017.09.010. PMID 29128083.
  11. ↑ Sanduzzi Zamparelli M, Rocco A, Compare D, Nardone G (2017). “The gut microbiota: A new potential driving force in liver cirrhosis and hepatocellular carcinoma”. United European Gastroenterol J. 5 (7): 944–953. doi:10.1177/2050640617705576. PMC 5676553. PMID 29163959.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2] Mohamad Alkateb, MBBCh [3]