Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Hereditary motor and sensory neuropathy

Introduction

Overview

Overview

Hereditary motor and sensory neuropathies (HMSN) are a group of neuropathies which are characterized by their impact upon both afferent and efferent neural communication.

They are more common than hereditary sensory and autonomic neuropathies.[1]

Types

Types

In 1968, it was classified from groups I to VII:[2][3]

Type Name Diseases Database OMIM
I Charcot-Marie-Tooth disease 1 Template:DiseasesDB2 118220, 118200
II Charcot-Marie-Tooth disease 2 Template:DiseasesDB2 118210, 600882
III Dejerine Sottas syndrome Template:DiseasesDB2 145900
IV Refsum’s disease Template:DiseasesDB2 266500
V HMSN+hereditary spastic paraplegia – 600361
VI HMSN+hereditary optic atrophy Template:DiseasesDB2 601152
VII HMSN+retinitis pigmentosa Template:DiseasesDB2 –

HMSN is sometimes equated with Charcot-Marie-Tooth disease.[4][5]

References

References

  1. ↑ Houlden H, Blake J, Reilly MM (2004). “Hereditary sensory neuropathies”. Curr. Opin. Neurol. 17 (5): 569–77. PMID 15367861. Unknown parameter |month= ignored (help)
  2. ↑ “eMedicine – Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies : Article by Aamir Hashmat”.
  3. ↑ Dyck PJ, Lambert EH (1968). “Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. I. Neurologic, genetic, and electrophysiologic findings in hereditary polyneuropathies”. Arch. Neurol. 18 (6): 603–18. PMID 4297451. Unknown parameter |month= ignored (help)
  4. ↑ Horacek O, Mazanec R, Morris CE, Kobesova A (2007). “Spinal deformities in hereditary motor and sensory neuropathy: a retrospective qualitative, quantitative, genotypical, and familial analysis of 175 patients”. Spine. 32 (22): 2502–8. doi:10.1097/BRS.0b013e3181573d4e. PMID 18090092. Unknown parameter |month= ignored (help)
  5. ↑ Bertorini T, Narayanaswami P, Rashed H (2004). “Charcot-Marie-Tooth disease (hereditary motor sensory neuropathies) and hereditary sensory and autonomic neuropathies”. Neurologist. 10 (6): 327–37. doi:10.1097/01.nrl.0000145596.38640.27. PMID 15518599. Unknown parameter |month= ignored (help)
Further reading

Further reading

de:Hereditäre motorisch-sensible Neuropathie Template:PNS diseases of the nervous system