High endothelial venules

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

High endothelial venules, or HEVs, are a subtype of blood endothelium present within lymph nodes; used by various leukocytes to gain entry into the lymph node via the blood.^[1]

The HEVs are made up of cuboidal endothelial cells, with various receptors to allow entry/rolling interactions between leukocytes and the endothelium.

High endothelial venules are found in lymph nodes and tonsils and Peyer’s patches, but not in the thymus or spleen.^[2]

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