Health Dictionary
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Hip-1
Introduction
Overview
Huntingtin Interacting Protein or Hip-1 for short is a protein that interacts with the huntingtin protein. It is known to contain a domain homologous to the death effector domains (DED) found on proteins involved in apoptosis. It is believed that accumulation of high levels of the free form of this protein in the cell is one of the mechanisms by which neuron cell death is caused in Huntington’s Disease (via the caspase-3 route).