Howel-Evans syndrome is an extremely rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis). The effects on the palms and soles is called tylosis, and in Howel-Evans syndrome, there is a predisposition to oesophageal cancer, particularly squamous cell carcinoma.

Howel-Evans syndrome was described in 1996 as being identical with palmoplantar ectodermal dysplasia type III.

The skin is treated with a keratolytic (such as salicylic acid) to dissolve the excess skin, and systemic treatment with retinoids (derivatives of Vitamin A) may be given.