As with most types of electrolyte imbalance, the treatment of high blood chloride levels is based on correcting the underlying cause.

• If the patient is dehydrated, therapy consists of establishing and maintaining adequate hydration.
• If the condition is caused or exacerbated by medications or treatments, these may be altered or discontinued, if deemed prudent.
• If there is underlying kidney disease (which is likely if there are other electrolyte disturbances), then the patient will be referred to a nephrologist for further care.
• If there is an underlying dysfunction of the endocrine or hormone system, the patient will likely be referred to an endocrinologist for further assessment.