Hypoglycemia is a Greek word that means under-sweet blood. In 1922, hypoglycemia was first discovered by James Collip when he was working on purifying insulin. He injected insulin into a rabbit and realized a reduction in blood glucose levels. Collip injected of a large doses of insulin to the rabbit, that lead to coma and death of rabbit.

• In 1869, Paul Langerhans was the first who discovered a collection of cells within the pancreas. He called it islets of Langerhans.^[1]
• In 1901, Eugene Opie was the first who discovered that destruction of islet cells results in diabetes mellitus.
• In 1921, Frederick Banting and Charles Best, orthopedic surgeons were the first who discovered insulin in the pancreatic extracts of dogs. With help of James B. Collip and J.J.R. Macleod, they developed insulin for human treatment. Nobel Prize was awarded to Banting and Macleod for this discovery.
• In 1922, hypoglycemia was first discovered by James Collip when he was working on purifying insulin. He injected insulin into a rabbit and realized the reduction in blood glucose levels. Collip discovered that injection of a large dose of insulin, the rabbit got into a coma and died.
• Hypoglycemia is a Greek word means under-sweet blood.