Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Hypoplastic left heart syndrome causes
Introduction
Overview
Overview
As with most congenital heart defects, there is no known cause. Approximately 10% of patients with hypoplastic left heart syndrome also have other birth defects.
Causes
Causes
While many authorities believe the cause of hypoplastic left heart syndrome (HLHS) is unknown,[1] [2][3] recent research indicates that HLHS may be due to genetic factors. [4][5] There is evidence associates hypoplastic left heart syndrome with gap junction protein, alpha 1.[6]
References
References
- ↑ “Hypoplastic Left Heart Syndrome Causes – Mayo Clinic”. Retrieved 2008-01-09.
- ↑ Hypoplastic Left Heart Syndrome : Article by P Syamasundar Rao, MD at eMedicine
- ↑ MedlinePlus Encyclopedia Hypoplastic left heart
- ↑ “Hypoplastic left heart syndrome likely caused by genetic factors”. Retrieved 2008-01-09.
- ↑ Dasgupta C, Martinez AM, Zuppan CW, Shah MM, Bailey LL, Fletcher WH (2001). “Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE)”. Mutat. Res. 479 (1–2): 173–86. doi:10.1016/S0027-5107(01)00160-9. PMID 11470490.
- ↑ Online Mendelian Inheritance in Man (OMIM) HYPOPLASTIC LEFT HEART SYNDROME -241550
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S.[2], Cafer Zorkun, M.D., Ph.D. [3], Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S.[5]