Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
IFNB1
Introduction
Interferon beta is a protein that in humans is encoded by the IFNB1 gene.[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.[2]
Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.
References
References
{shfhfekg1215ο½
Further reading
Further reading
- Biron CA, Nguyen KB, Pien GC (2002). “Innate immune responses to LCMV infections: natural killer cells and cytokines”. Curr. Top. Microbiol. Immunol. 263: 7β27. doi:10.1007/978-3-642-56055-2_2. PMIDΒ 11987821.
- Conti L, Fantuzzi L, Del CornΓ² M, et al. (2005). “Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis”. Immunobiology. 209 (1β2): 99β115. doi:10.1016/j.imbio.2004.02.008. PMIDΒ 15481145.
- Bekisz J, Schmeisser H, Hernandez J, et al. (2005). “Human interferons alpha, beta and omega”. Growth Factors. 22 (4): 243β51. doi:10.1080/08977190400000833. PMIDΒ 15621727.
- Copeland KF (2006). “Modulation of HIV-1 transcription by cytokines and chemokines”. Mini Reviews in Medicinal Chemistry. 5 (12): 1093β101. doi:10.2174/138955705774933383. PMIDΒ 16375755.
- Silverman RH, Sengupta DN (1991). “Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes”. J. Exp. Pathol. 5 (2): 69β77. PMIDΒ 1708818.
- Flores I, Mariano TM, Pestka S (1991). “Human interferon omega (omega) binds to the alpha/beta receptor”. J. Biol. Chem. 266 (30): 19875β7. PMIDΒ 1834641.
- May LT, Sehgal PB (1985). “On the relationship between human interferon alpha 1 and beta 1 genes”. J. Interferon Res. 5 (3): 521β6. PMIDΒ 2414376.
- Francois DT, Katona IM, June CH, et al. (1988). “Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens”. Clin. Immunol. Immunopathol. 48 (3): 297β306. doi:10.1016/0090-1229(88)90023-2. PMIDΒ 3135963.
- Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). “Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line”. J. Biol. Chem. 262 (30): 14600β5. PMIDΒ 3667593.
- Blank KJ, McKernan LN, Murasko DM (1985). “Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation”. J. Interferon Res. 5 (1): 215β21. doi:10.1089/jir.1985.5.215. PMIDΒ 3872918.
- Derynck R, Content J, DeClercq E, et al. (1980). “Isolation and structure of a human fibroblast interferon gene”. Nature. 285 (5766): 542β7. doi:10.1038/285542a0. PMIDΒ 6157094.
- Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). “The nucleotide sequence of human fibroblast interferon cDNA”. Gene. 10 (1): 11β5. doi:10.1016/0378-1119(80)90138-9. PMIDΒ 6157601.
- Houghton M, Easton MA, Stewart AG, et al. (1981). “The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase”. Nucleic Acids Res. 8 (13): 2885β94. doi:10.1093/nar/8.13.2885. PMCΒ 324132. PMIDΒ 6159580.
- Goeddel DV, Shepard HM, Yelverton E, et al. (1981). “Synthesis of human fibroblast interferon by E. coli”. Nucleic Acids Res. 8 (18): 4057β74. doi:10.1093/nar/8.18.4057. PMCΒ 324219. PMIDΒ 6159584.
- Houghton M, Stewart AG, Doel SM, et al. (1981). “The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers”. Nucleic Acids Res. 8 (9): 1913β31. doi:10.1093/nar/8.9.1913. PMCΒ 324047. PMIDΒ 6159597.
- Wetzel R (1981). “Assignment of the disulphide bonds of leukocyte interferon”. Nature. 289 (5798): 606β7. doi:10.1038/289606a0. PMIDΒ 6162107.
- Lawn RM, Adelman J, Franke AE, et al. (1981). “Human fibroblast interferon gene lacks introns”. Nucleic Acids Res. 9 (5): 1045β52. doi:10.1093/nar/9.5.1045. PMCΒ 326735. PMIDΒ 6164984.
- Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). “A single amino acid change in IFN-beta1 abolishes its antiviral activity”. Nature. 294 (5841): 563β5. doi:10.1038/294563a0. PMIDΒ 6171735.
- Content J, De Wit L, Pierard D, et al. (1982). “Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta”. Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768β72. doi:10.1073/pnas.79.9.2768. PMCΒ 346287. PMIDΒ 6178110.
- Fiers W, Remaut E, Devos R, et al. (1983). “The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29β38. doi:10.1098/rstb.1982.0103. PMIDΒ 6183692.
{jenfjw}