Health Dictionary
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IHH
Introduction
Indian hedgehog homolog (Drosophila), also known as IHH, is a human gene.[1]
Further reading
Further reading
- Marigo V, Roberts DJ, Lee SM; et al. (1995). “Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog”. Genomics. 28 (1): 44–51. PMID 7590746.
- Chang DT, López A, von Kessler DP; et al. (1995). “Products, genetic linkage and limb patterning activity of a murine hedgehog gene”. Development. 120 (11): 3339–53. PMID 7720571.
- Porter JA, Young KE, Beachy PA (1996). “Cholesterol modification of hedgehog signaling proteins in animal development”. Science. 274 (5285): 255–9. PMID 8824192.
- Leek JP, Moynihan TP, Anwar R; et al. (1997). “Assignment of Indian hedgehog (IHH) to human chromosome bands 2q33–>q35 by in situ hybridization”. Cytogenet. Cell Genet. 76 (3–4): 187–8. PMID 9186520.
- Pepinsky RB, Zeng C, Wen D; et al. (1998). “Identification of a palmitic acid-modified form of human Sonic hedgehog”. J. Biol. Chem. 273 (22): 14037–45. PMID 9593755.
- Carpenter D, Stone DM, Brush J; et al. (1998). “Characterization of two patched receptors for the vertebrate hedgehog protein family”. Proc. Natl. Acad. Sci. U.S.A. 95 (23): 13630–4. PMID 9811851.
- Chuang PT, McMahon AP (1999). “Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein”. Nature. 397 (6720): 617–21. doi:10.1038/17611. PMID 10050855.
- Ito H, Akiyama H, Shigeno C; et al. (1999). “Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair”. Biochem. Biophys. Res. Commun. 262 (2): 443–51. doi:10.1006/bbrc.1999.1197. PMID 10462495.
- Bak M, Hansen C, Friis Henriksen K, Tommerup N (2001). “The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21–>q31.3”. Cytogenet. Cell Genet. 92 (3–4): 300–3. PMID 11435703.
- Gao B, Guo J, She C; et al. (2001). “Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1”. Nat. Genet. 28 (4): 386–8. doi:10.1038/ng577. PMID 11455389.
- Gritli-Linde A, Lewis P, McMahon AP, Linde A (2001). “The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides”. Dev. Biol. 236 (2): 364–86. doi:10.1006/dbio.2001.0336. PMID 11476578.
- Kindblom JM, Nilsson O, Hurme T; et al. (2002). “Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development”. J. Endocrinol. 174 (2): R1–6. PMID 12176676.
- Cormier S, Delezoide AL, Benoist-Lasselin C; et al. (2002). “Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations”. Am. J. Pathol. 161 (4): 1325–35. PMID 12368206.
- McCready ME, Sweeney E, Fryer AE; et al. (2002). “A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved”. Hum. Genet. 111 (4–5): 368–75. doi:10.1007/s00439-002-0815-2. PMID 12384778.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kirkpatrick TJ, Au KS, Mastrobattista JM; et al. (2003). “Identification of a mutation in the Indian Hedgehog (IHH) gene causing brachydactyly type A1 and evidence for a third locus”. J. Med. Genet. 40 (1): 42–4. PMID 12525541.
- Hellemans J, Coucke PJ, Giedion A; et al. (2003). “Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips”. Am. J. Hum. Genet. 72 (4): 1040–6. PMID 12632327.
- Niemann C, Unden AB, Lyle S; et al. (2003). “Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis”. Proc. Natl. Acad. Sci. U.S.A. 100 Suppl 1: 11873–80. doi:10.1073/pnas.1834202100. PMID 12917489.
- Berman DM, Karhadkar SS, Maitra A; et al. (2003). “Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours”. Nature. 425 (6960): 846–51. doi:10.1038/nature01972. PMID 14520411.
- Garcia-Barceló MM, Lee WS, Sham MH; et al. (2004). “Is there a role for the IHH gene in Hirschsprung’s disease?”. Neurogastroenterol. Motil. 15 (6): 663–8. PMID 14651602.