Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
IL1RAP
Introduction
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[1][2][3]
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[3]
Interactions
Interactions
IL1RAP has been shown to interact with TOLLIP[4] and Interleukin 1 receptor, type I.[5]
References
References
- ↑ Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). “The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping”. Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
- ↑ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). “The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)”. J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
- ↑ 3.0 3.1 “Entrez Gene: IL1RAP interleukin 1 receptor accessory protein”.
- ↑ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). “Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor”. Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
- ↑ Huang, J; Gao X; Li S; Cao Z (November 1997). “Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS…9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.
Further reading
Further reading
- Greenfeder SA, Nunes P, Kwee L, et al. (1995). “Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex”. J. Biol. Chem. 270 (23): 13757–65. doi:10.1074/jbc.270.23.13757. PMID 7775431.
- Parnet P, Garka KE, Bonnert TP, et al. (1996). “IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP”. J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
- Huang J, Gao X, Li S, Cao Z (1998). “Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein”. Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS…9412829H. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
- Cullinan EB, Kwee L, Nunes P, et al. (1998). “IL-1 receptor accessory protein is an essential component of the IL-1 receptor”. J. Immunol. 161 (10): 5614–20. PMID 9820540.
- Lang D, Knop J, Wesche H, et al. (1999). “The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness”. J. Immunol. 161 (12): 6871–7. PMID 9862719.
- Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). “Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells”. FEBS Lett. 442 (1): 57–60. doi:10.1016/S0014-5793(98)01623-8. PMID 9923604.
- Sizemore N, Leung S, Stark GR (1999). “Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit”. Mol. Cell. Biol. 19 (7): 4798–805. PMC 84278. PMID 10373529.
- Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). “IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein”. J. Immunol. 164 (10): 5277–86. doi:10.4049/jimmunol.164.10.5277. PMID 10799889.
- Burns K, Clatworthy J, Martin L, et al. (2000). “Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor”. Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
- Bigonnesse F, Marois M, Maheux R, Akoum A (2001). “Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle”. Mol. Hum. Reprod. 7 (4): 333–9. doi:10.1093/molehr/7.4.333. PMID 11279295.
- Jefferies C, Bowie A, Brady G, et al. (2001). “Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1” (PDF). Mol. Cell. Biol. 21 (14): 4544–52. doi:10.1128/MCB.21.14.4544-4552.2001. PMC 87113. PMID 11416133.
- Radons J, Gabler S, Wesche H, et al. (2002). “Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling”. J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ruhul Amin AR, Machida K, Oshima K, et al. (2003). “A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling”. Oncogene. 21 (57): 8871–8. doi:10.1038/sj.onc.1206018. PMID 12483539.
- Smith DE; Hanna R; Della Friend; et al. (2003). “The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action”. Immunity. 18 (1): 87–96. doi:10.1016/S1074-7613(02)00514-9. PMID 12530978.
- Boch JA, Yoshida Y, Koyama Y, et al. (2003). “Characterization of a cascade of protein interactions initiated at the IL-1 receptor”. Biochem. Biophys. Res. Commun. 303 (2): 525–31. doi:10.1016/S0006-291X(03)00385-1. PMID 12659850.
- Bin LH, Xu LG, Shu HB (2003). “TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling”. J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
- Jensen LE, Whitehead AS (2004). “Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis”. Cell. Signal. 15 (8): 793–802. doi:10.1016/S0898-6568(03)00039-1. PMID 12781872.