Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
IRX4
Introduction
Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.[1][2]
Function
Function
IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1]
References
References
- ↑ 1.0 1.1 “Entrez Gene: iroquois homeobox 4”.
- ↑ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). “Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand”. Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.
Further reading
Further reading
- Lewis MT, Ross S, Strickland PA, et al. (1999). “Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast”. Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
- Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). “Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression”. J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777.
- Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). “Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy”. Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
- Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). “Common genetic variation and performance on standardized cognitive tests”. European Journal of Human Genetics. 18 (7): HASH(0x24ee8d0). doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.