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ITGA2B
Introduction
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.
ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]
References
References
- ā “Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)”.
- ā Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). “Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3”. J. Biol. Chem. United States. 277 (32): 28934ā41. doi:10.1074/jbc.M204340200. ISSNĀ 0021-9258. PMIDĀ 12042322.
- ā Larkin, Deirdre; Murphy Derek; Reilly Dermot F; Cahill Martha; Sattler Ellen; Harriott Pat; Cahill Dolores J; Moran Niamh (Jun 2004). “ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation”. J. Biol. Chem. United States. 279 (26): 27286ā93. doi:10.1074/jbc.M402159200. ISSNĀ 0021-9258. PMIDĀ 15075326.
Further reading
Further reading
- Bray PF (1995). “Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization”. Thromb. Haemost. 72 (4): 492ā502. PMIDĀ 7878622.
- Naik UP, Parise LV (1997). “Structure and function of platelet alpha IIb beta 3”. Curr. Opin. Hematol. 4 (5): 317ā22. PMIDĀ 9288464.
- Porter JC, Hogg N (1999). “Integrins take partners: cross-talk between integrins and other membrane receptors”. Trends Cell Biol. 8 (10): 390ā6. doi:10.1016/S0962-8924(98)01344-0. PMIDĀ 9789327.
- Lincoff AM (1998). “Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization”. Am. J. Cardiol. 82 (8B): 36Pā42P. doi:10.1016/S0002-9149(98)00662-6. PMIDĀ 9809890.
- Bennett JS (2001). “Platelet-fibrinogen interactions”. Ann. N. Y. Acad. Sci. 936: 340ā54. doi:10.1111/j.1749-6632.2001.tb03521.x. PMIDĀ 11460491.
- Plow EF, Cierniewski CS, Xiao Z, et al. (2002). “AlphaIIbbeta3 and its antagonism at the new millennium”. Thromb. Haemost. 86 (1): 34ā40. PMIDĀ 11487023.
- Quinn MJ, Byzova TV, Qin J, et al. (2004). “Integrin alphaIIbbeta3 and its antagonism”. Arterioscler. Thromb. Vasc. Biol. 23 (6): 945ā52. doi:10.1161/01.ATV.0000066686.46338.F1. PMIDĀ 12637342.
- Fullard JF (2004). “The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis”. Curr. Pharm. Des. 10 (14): 1567ā76. doi:10.2174/1381612043384682. PMIDĀ 15134555.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). “GPVI and integrin alphaIIb beta3 signaling in platelets”. J. Thromb. Haemost. 3 (8): 1752ā62. doi:10.1111/j.1538-7836.2005.01429.x. PMIDĀ 16102042.
- Bennett JS (2006). “Structure and function of the platelet integrin alphaIIbbeta3”. J. Clin. Invest. 115 (12): 3363ā9. doi:10.1172/JCI26989. PMCĀ 1297263. PMIDĀ 16322781.
- Ma YQ, Qin J, Plow EF (2007). “Platelet integrin alpha(IIb)beta(3): activation mechanisms”. J. Thromb. Haemost. 5 (7): 1345ā52. doi:10.1111/j.1538-7836.2007.02537.x. PMIDĀ 17635696.
External links
External links
- CD41+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)