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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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ITGA6

Introduction

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

Interactions

ITGA6 has been shown to interact with TSPAN4[2] and GIPC1.[3]

See also

See also

References

References

  1. ↑ “Entrez Gene: ITGA6 integrin, alpha 6”.
  2. ↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). “NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins”. The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  3. ↑ Tani TT, Mercurio AM (September 2001). “PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B”. The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
Further reading

Further reading

  • Lipscomb EA, Mercurio AM (September 2005). “Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression”. Cancer Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.
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