Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ITIH4
Introduction
Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.[1][2][3]
References
References
- ↑ Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). “The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human”. Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
- ↑ Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). “cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein”. FEBS Lett. 357 (2): 207–11. doi:10.1016/0014-5793(94)01364-7. PMID 7805892.
- ↑ “Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)”.
Further reading
Further reading
- Choi-Miura NH, Sano Y, Oda E, et al. (1995). “Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma”. J. Biochem. 117 (2): 400–7. doi:10.1093/jb/117.2.400. PMID 7541790.
- Tobe T, Saguchi K, Hashimoto K, et al. (1995). “Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14”. Cytogenet. Cell Genet. 71 (3): 296–8. doi:10.1159/000134130. PMID 7587397.
- Saguchi K, Tobe T, Hashimoto K, et al. (1995). “Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein”. J. Biochem. 117 (1): 14–8. PMID 7775381.
- Saguchi K, Tobe T, Hashimoto K, et al. (1997). “Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)”. J. Biochem. 119 (5): 898–905. doi:10.1093/oxfordjournals.jbchem.a021327. PMID 8797089.
- Jean L, Smih F, Olivier E, et al. (1997). “Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14”. Genomics. 41 (1): 139–40. doi:10.1006/geno.1997.4612. PMID 9126497.
- Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). “Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage”. J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
- Tozaki T, Choi-Miura NH, Taniyama M, et al. (2003). “SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method”. BMC Med. Genet. 3: 6. doi:10.1186/1471-2350-3-6. PMCÂ 117798. PMIDÂ 12147176.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry”. Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
- Fujita Y, Ezura Y, Emi M, et al. (2004). “Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene”. J. Hum. Genet. 49 (1): 24–8. doi:10.1007/s10038-003-0101-8. PMID 14661079.
- Anderson NL, Polanski M, Pieper R, et al. (2004). “The human plasma proteome: a nonredundant list developed by combination of four separate sources”. Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- Bunkenborg J, Pilch BJ, Podtelejnikov AV, WiÅ›niewski JR (2004). “Screening for N-glycosylated proteins by liquid chromatography mass spectrometry”. Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
- Kroczynska B, King-Simmons L, Alloza L, et al. (2006). “BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4”. Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry”. J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.