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Ifenprodil
Introduction
Overview
Overview
Ifenprodil is a selective inhibitor of the NMDA receptor.[1] Its effect is specific to receptors composed of the NR1 (glycine-binding NMDA receptor subunit 1; GluN1) and NR2B (glutamate-binding NMDA receptor subunit 2; GluN2B) subunits.[2]
NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.
References
References
- ↑ Reynolds IJ, Miller RJ (1989). “Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines”. Mol. Pharmacol. 36 (5): 758–65. PMID 2555674.
- ↑ Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr (Dec 2011). “Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects”. Steroids. 76 (13): 1409–18. doi:10.1016/j.steroids.2011.09.002. PMID 21925193.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]