IgA nephropathy history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2], Rim Halaby, M.D. [3]

Overview

The majority of patients with IgA nephropathy are asymptomatic. Some patients with IgA nephropathy may develop intermittent gross hematuria which is often termed as synpharyngitic hematuria, because it occurs after the episodes of bacterial tonsillitis or viral URTI’s. The patient may also have a positive history of flank pain, low grade fever.

History and Symptoms

The majority of patients with IgA nephropathy may be asymptomatic.

History

Patients with IgA nephropathy may have a positive history of:^[1]^[2]

Intermittent gross hematuria
Synpharyngitic hematuria
The precipitating factors for synpharyngitic hematuria are:
- Bacterial tonsillitis
- Viral URTI’s
Microscopic hematuria
Flank pain
Low grade fever
Mild proteinuria

Common Symptoms

Common symptoms of IgA nephropathy include:^[3]^[4]

Less Common Symptoms

Less common symptoms of IgA nephropathy include: ^[5]

References

↑ Galla JH (February 1995). “IgA nephropathy”. Kidney Int. 47 (2): 377–87. PMID 7723227.
↑ Donadio JV, Grande JP (September 2002). “IgA nephropathy”. N. Engl. J. Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.
↑ Hall CL, Bradley R, Kerr A, Attoti R, Peat D (October 2004). “Clinical value of renal biopsy in patients with asymptomatic microscopic hematuria with and without low-grade proteinuria”. Clin. Nephrol. 62 (4): 267–72. PMID 15524056.
↑ Topham PS, Harper SJ, Furness PN, Harris KP, Walls J, Feehally J (June 1994). “Glomerular disease as a cause of isolated microscopic haematuria”. Q. J. Med. 87 (6): 329–35. PMID 8041865.
↑ Gutierrez, E.; Gonzalez, E.; Hernandez, E.; Morales, E.; Martinez, M. A.; Usera, G.; Praga, M. (2006). “Factors That Determine an Incomplete Recovery of Renal Function in Macrohematuria-Induced Acute Renal Failure of IgA Nephropathy”. Clinical Journal of the American Society of Nephrology. 2 (1): 51–57. doi:10.2215/CJN.02670706. ISSN 1555-9041.

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[pmid7723227-1] Galla JH (February 1995). “IgA nephropathy”. Kidney Int. 47 (2): 377–87. PMID 7723227.

[pmid12213946-2] Donadio JV, Grande JP (September 2002). “IgA nephropathy”. N. Engl. J. Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.

[pmid15524056-3] Hall CL, Bradley R, Kerr A, Attoti R, Peat D (October 2004). “Clinical value of renal biopsy in patients with asymptomatic microscopic hematuria with and without low-grade proteinuria”. Clin. Nephrol. 62 (4): 267–72. PMID 15524056.

[pmid8041865-4] Topham PS, Harper SJ, Furness PN, Harris KP, Walls J, Feehally J (June 1994). “Glomerular disease as a cause of isolated microscopic haematuria”. Q. J. Med. 87 (6): 329–35. PMID 8041865.

[GutierrezGonzalez2006-5] Gutierrez, E.; Gonzalez, E.; Hernandez, E.; Morales, E.; Martinez, M. A.; Usera, G.; Praga, M. (2006). “Factors That Determine an Incomplete Recovery of Renal Function in Macrohematuria-Induced Acute Renal Failure of IgA Nephropathy”. Clinical Journal of the American Society of Nephrology. 2 (1): 51–57. doi:10.2215/CJN.02670706. ISSN 1555-9041.

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