IgA nephropathy laboratory findings

There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy. However all patients with biopsy-proven IgA nephropathy are assessed for secondary causes to rule out common causes of secondary IgA nephropathy. The viral serologies for HIV, HBV, HCV, Liver function tests, and Electrophoresis of serum immunoglobulins are performed. Blood pressure measurement, serum creatinine to estimate glomerular filtration rate , Proteinuria, and pathological features are monitored to assess the risk of progression of the disease.

• There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.^[1][2]
• Some patients with IgA nephropathy may have elevated concentration of serum total IgA.
  • There is not enough evidence of serum total IgA concentration for the measurement of the severity or activity of IgA nephropathy.
• The urinary Immunoglobulins are not distinctive in IgA nephropathy.

• Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
  • Viral serologies:
    • HIV
    • HBV
    • HCV
  • Liver function tests
  • Electrophoresis of serum immunoglobulins
• Assess the risk of progression and prognosis by the following parameters at diagnosis and at follow-up:
  • Blood pressure measurement
  • Serum creatinine to estimate glomerular filtration rate (GFR)
  • Proteinuria
  • Pathological features
• A kidney biopsy is to be considered only if signs of acute kidney injury and macroscopic hematuria persist for at least 5 days since the onset of kidney injury.

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