Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Immune compromise

Introduction

Synonyms and keywords: Immune deficiency; immunity suppression; immunological deficiency; immunosuppression

Overview

Overview

Immunodeficiency can be caused by a variety of conditions including autoimmunity, infections, congenital defects, complement defects, or auto-inflammatory states.

Classification

Classification

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Immunodeficiency
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Immunodeficiency affecting cellular and humoral Immunity
 
Combined immunodeficiency
 
Predominantly antibody deficiency
 
Diseases of immune dysregulation
 
Congenital defects of phagocytes
 
Defects in intrinsic and innate immunity
 
Auto-inflammatory disorders
 
Complement deficiencies
 
Phenocopies of primary immunodeficiency (PID)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Severe combined
immunodeficiency (SCID)
 
 
Combined immunodeficiency
with associated features
 
 
Hypogammaglobulinemia
 
 
Hemophagocytic lymphohistiocytosis (HLH)
& EBV susceptibility
 
 
Congenital defects of
phagocyte number
 
 
Bacterial and
parasitic infections
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Combined immunodeficiencies
generally less pronounced than
severe combined immunodeficiency
 
 
Combined immunodeficiency
with syndromic features
 
 
Other antibody
deficiencies
 
 
Syndromes with
autoimmunity and others
 
 
Congenital defects of
phagocyte function
 
 
Mendelian susceptibility to
mycobacterial disease (MSMD)
& viral infections
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
References

References

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[3], Ali Akram, M.B.B.S.[4], Zahir Ali Shaikh, MD[5] , Syed Musadiq Ali M.B.B.S.[6], Sabawoon Mirwais, M.B.B.S, M.D.[7]