Inappropriate sinus tachycardia pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The mechanism of the arrhythmia primarily involves the sinus node and peri-nodal tissue^[1] and does not require the AV node for maintenance. These patients have no apparent heart disease or other causes of sinus tachycardia. IST is thought to be due to abnormal autonomic control or dysautonomia. An autoimmune mechanism has been suggested as several studies have detected autoantibodies that activate beta adrenoreceptors in a portion of patients.^[2]^[3]

References

↑ Sato, Toshiaki; Mitamura, Hideo; Murata, Mitsushige; Shinagawa, Kaori; Miyoshi, Shunichiro; Kanki, Hideaki; Takatsuki, Seiji; Soejima, Kyoko; Miyazaki, Toshihisa (2000). “Electrophysiologic findings of a patient with inappropriate sinus tachycardia cured by selective radiofrequency catheter ablation”. Journal of Electrocardiology. 33 (4): 381–6. doi:10.1054/jelc.2000.9648. PMID 11099363.
↑ Chiale, Pablo A.; Garro, Hugo A.; Schmidberg, Jorge; Sánchez, Rubén A.; Acunzo, Rafael S.; Lago, Manuel; Levy, Gabriela; Levin, Mariano (2006). “Inappropriate sinus tachycardia may be related to an immunologic disorder involving cardiac β andrenergic receptors”. Heart Rhythm. 3 (10): 1182–6. doi:10.1016/j.hrthm.2006.06.011. PMID 17018348.
↑ Nattel, Stanley (2006). “Inappropriate sinus tachycardia and beta-receptor autoantibodies: A mechanistic breakthrough?”. Heart Rhythm. 3 (10): 1187–8. doi:10.1016/j.hrthm.2006.07.019. PMID 17018349.

Template:WikiDoc Sources

[1] Sato, Toshiaki; Mitamura, Hideo; Murata, Mitsushige; Shinagawa, Kaori; Miyoshi, Shunichiro; Kanki, Hideaki; Takatsuki, Seiji; Soejima, Kyoko; Miyazaki, Toshihisa (2000). “Electrophysiologic findings of a patient with inappropriate sinus tachycardia cured by selective radiofrequency catheter ablation”. Journal of Electrocardiology. 33 (4): 381–6. doi:10.1054/jelc.2000.9648. PMID 11099363.

[2] Chiale, Pablo A.; Garro, Hugo A.; Schmidberg, Jorge; Sánchez, Rubén A.; Acunzo, Rafael S.; Lago, Manuel; Levy, Gabriela; Levin, Mariano (2006). “Inappropriate sinus tachycardia may be related to an immunologic disorder involving cardiac β andrenergic receptors”. Heart Rhythm. 3 (10): 1182–6. doi:10.1016/j.hrthm.2006.06.011. PMID 17018348.

[3] Nattel, Stanley (2006). “Inappropriate sinus tachycardia and beta-receptor autoantibodies: A mechanistic breakthrough?”. Heart Rhythm. 3 (10): 1187–8. doi:10.1016/j.hrthm.2006.07.019. PMID 17018349.

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Inappropriate sinus tachycardia pathophysiology

Overview

References

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