Health Dictionary
Reliable, easy-to-read patient information on common medical conditions â written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Insulinoma laboratory tests
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of insulinoma include serum glucose < 55 mg/dL, serum Insulin > 5-10 ΌU/mL, serum C-Peptide > 200 pmol/L, and serum proinsulin ⥠22 pmol/L. Patients with insulinoma may have elevated insulin to glucose ratio of > 0.4, which is usually suggestive of insulinoma after a 72-hour fast test(gold standard test). 33% patients have clinical symptoms within 12 hours of the fasting, 80% develop within 24 hours, 90% develop within 48 hours, and 100% develop within 72 hours.
Laboratory Findings
Laboratory Findings
- Laboratory findings consistent with the diagnosis of insulinoma include:[1]
- Serum glucose < 55 mg/dL
- Serum Insulin > 5-10 ÎŒU/mL
- Serum C-Peptide > 200 pmol/L
- Serum proinsulin ⥠22 pmol/L
- Patients with insulinoma may have elevated insulin to glucose ratio of > 0.4, which is usually suggestive of insulinoma after a 72-hour fast test. It is a gold standard test. [2]
References
References
- â Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER; et al. (2009). “Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline”. J Clin Endocrinol Metab. 94 (3): 709â28. doi:10.1210/jc.2008-1410. PMIDÂ 19088155.
- â Callender GG, Rich TA, Perrier ND (2008). “Multiple endocrine neoplasia syndromes”. Surg Clin North Am. 88 (4): 863â95, viii. doi:10.1016/j.suc.2008.05.001. PMIDÂ 18672144.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]