Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Integrase inhibitor
Introduction
Integrase inhibitors are a class of antiretroviral drug developed for the treatment of HIV infection. They block the action of integrase, an enzyme that integrates genetic material from the virus into its target cell. No integrase inhibitors have yet received governmental approval, although two are currently undergoing testing.
Drugs under development
Drugs under development
- MK-0518, developed by Merck & Co., has entered Phase III clinical trials.
- GS 9137 or JTK-303, licensed by Gilead Sciences from Japan Tobacco.
External links
External links
- MK-0518, the first Integrase Inhibitor for HIV
- HIV Antiretroviral Agents in Development
- integrase+inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
- Savarino A. A historical sketch of the discovery and development of HIV-1 integrase inhibitors. Expert Opin Investig Drugs. 2006 Dec;15(12):1507-22. [1]]