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Interferon alfacon-1 contraindications

Introduction

Interferon alfacon-1
INFERGEN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages
Contraindications

Contraindications

INFERGEN is contraindicated in patients with

  • hepatic decompensation (Child-Pugh score >6 [class B and C])
  • autoimmune hepatitis
  • known hypersensitivity reactions such as urticaria, angioedema, bronchoconstriction, anaphylaxis to interferon alphas or to any component of the product

Additionally, ribavirin is contraindicated in:

  • women who are pregnant
  • men whose female partners are pregnant
  • patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia)
  • patients with hypersensitivity to ribavirin or any other component of the product
  • patients with creatinine clearance <50 mL/min.[1]
References

References

Adapted from the FDA Package Insert.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sophia Saad, Associate Editor – WikiDoc [2]