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Interleukin 12 receptor, beta 2 subunit
Introduction
Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.[1] IL12RB2 orthologs[2] have been identified in all mammals for which complete genome data are available.
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12RĪ²1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12RĪ²1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12RĪ²2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.[3] The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn’s disease and leprosy, which is thought to contribute to the inflammatory response and host defense.[1]
Interactions
Interactions
Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.[4]
RNA editing
RNA editing
The mRNA of this protein is subject to RNA editing.
References
References
- ā 1.0 1.1 “Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2”.
- ā “OrthoMaM phylogenetic marker: IL12RB2 coding sequence”.
- ā Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ (September 2012). “T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor Ī²2”. Immunity. 37 (3): 501ā10. doi:10.1016/j.immuni.2012.05.031. PMIDĀ 22960221.
- ā Yamamoto, K; Shibata F; Miura O; Kamiyama R; Hirosawa S; Miyasaka N (Apr 1999). “Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus”. Biochem. Biophys. Res. Commun. UNITED STATES. 257 (2): 400ā4. doi:10.1006/bbrc.1999.0479. ISSNĀ 0006-291X. PMIDĀ 10198225.
Further reading
Further reading
- Airoldi I, Guglielmino R, Carra G, et al. (2002). “The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes”. Haematologica. 87 (4): 434ā42. PMIDĀ 11940489.
- Chua AO, Chizzonite R, Desai BB, et al. (1994). “Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130”. J. Immunol. 153 (1): 128ā36. PMIDĀ 7911493.
- Andrew SE, Goldberg YP, Kremer B, et al. (1993). “The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease”. Nat. Genet. 4 (4): 398ā403. doi:10.1038/ng0893-398. PMIDĀ 8401589.
- Presky DH, Yang H, Minetti LJ, et al. (1997). “A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002ā7. Bibcode:1996PNAS…9314002P. doi:10.1073/pnas.93.24.14002. PMCĀ 19484. PMIDĀ 8943050.
- Zou J, Presky DH, Wu CY, Gubler U (1997). “Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases”. J. Biol. Chem. 272 (9): 6073ā7. doi:10.1074/jbc.272.9.6073. PMIDĀ 9038232.
- Rogge L, Barberis-Maino L, Biffi M, et al. (1997). “Selective expression of an interleukin-12 receptor component by human T helper 1 cells”. J. Exp. Med. 185 (5): 825ā31. doi:10.1084/jem.185.5.825. PMCĀ 2196163. PMIDĀ 9120388.
- Yamamoto K, Kobayashi H, Miura O, et al. (1997). “Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization”. Cytogenet. Cell Genet. 77 (3ā4): 257ā8. doi:10.1159/000134589. PMIDĀ 9284929.
- Presky DH, Minetti LJ, Gillessen S, et al. (1998). “Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex”. J. Immunol. 160 (5): 2174ā9. PMIDĀ 9498755.
- Morton SM, Bocaccio I, Depetris D, et al. (1998). “Assignment of IL12RB2 to human chromosome 1p31.3āp31.2 between D1S230 and D1S198”. Cytogenet. Cell Genet. 79 (3ā4): 282ā3. doi:10.1159/000134743. PMIDĀ 9605872.
- Naeger LK, McKinney J, Salvekar A, Hoey T (1999). “Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling”. J. Biol. Chem. 274 (4): 1875ā8. doi:10.1074/jbc.274.4.1875. PMIDĀ 9890938.
- Yamamoto K, Shibata F, Miura O, et al. (1999). “Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus”. Biochem. Biophys. Res. Commun. 257 (2): 400ā4. doi:10.1006/bbrc.1999.0479. PMIDĀ 10198225.
- Yao BB, Niu P, Surowy CS, Faltynek CR (1999). “Direct interaction of STAT4 with the IL-12 receptor”. Arch. Biochem. Biophys. 368 (1): 147ā55. doi:10.1006/abbi.1999.1302. PMIDĀ 10415122.
- Matsui E, Kaneko H, Fukao T, et al. (2000). “Mutations of the IL-12 receptor beta2 chain gene in atopic subjects”. Biochem. Biophys. Res. Commun. 266 (2): 551ā5. doi:10.1006/bbrc.1999.1859. PMIDĀ 10600539.
- van Rietschoten JG, Smits HH, Westland R, et al. (2000). “Genomic organization of the human interleukin-12 receptor beta2-chain gene”. Immunogenetics. 51 (1): 30ā6. doi:10.1007/s002510050005. PMIDĀ 10663559.
- van Rietschoten JG, Smits HH, van de Wetering D, et al. (2001). “Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells”. J. Biol. Chem. 276 (37): 34509ā16. doi:10.1074/jbc.M102536200. PMIDĀ 11438525.
- Kim J, Uyemura K, Van Dyke MK, et al. (2001). “A role for IL-12 receptor expression and signal transduction in host defense in leprosy”. J. Immunol. 167 (2): 779ā86. doi:10.4049/jimmunol.167.2.779. PMIDĀ 11441083.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899ā903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMCĀ 139241. PMIDĀ 12477932.
- Jones ML, Young JM, Huang QR, et al. (2003). “Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation”. AIDS Res. Hum. Retroviruses. 19 (4): 283ā92. doi:10.1089/088922203764969483. PMIDĀ 12804004.
- Yamamoto K, Yamaguchi M, Miyasaka N, Miura O (2003). “SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit”. Biochem. Biophys. Res. Commun. 310 (4): 1188ā93. doi:10.1016/j.bbrc.2003.09.140. PMIDĀ 14559241.