The majority of patients with interstitial nephritis are asymptomatic. However, nonspecific signs and symptoms may present depending upon underlying etiology and timing of presentation. Non specific symptoms include nausea, vomiting, malaise, and oliguria. Hematuria though not so common is also seen in some patients with interstitial nephritis. Other symptoms of interstitial nephritis include hypersensitivity reaction, such as rash, fever, and eosinophilia.

Patients with TIN may have a positive history of:

• Drugs consumption especially antibiotic as well NSAIDS
• Previous history of allergic drug reaction
• Infections
• Systemic disease including sarcoidosis, Sjogren’s syndrome, systemic lupus erythematosus (SLE).

The majority of patients with TIN are asymptomatic. however, when the nonspicific signs and symptoms do occur they are widely varied and can occur rapidly or gradually. When caused by an allergic-type reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients), rash (15% of patients), and eosinophilia (23% of patients). Some people experience dysuria, and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include hyperkalemia, metabolic acidosis, and kidney failure.^{[1][2][3][4][5][6]}

Common symptoms of interstitial nephritis include:

• Nausea
• Vomiting
• Malaise
• Oliguria
• Fever
• Rash

Less common symptoms of interstitial nephritis include:

• Gross hematuria^[7]
• Proteinuria^[8]