The differential diagnosis for jaundice and pruritis are:
| Disease
|
History and clinical manifestations
|
Diagnosis
|
| Lab Findings
|
Other blood tests
|
Other diagnostic
|
| AST
|
ALT
|
ALK
|
BLR Indirect
|
BLR Direct
|
Viral serology
|
| Type of jaundice
|
Pruritis
|
Family history
|
| Common bile duct stone
|
Cholestatic Jaundice
|
+
|
-/+
|
N
|
N
|
↑
|
N
|
↑
|
–
|
Dilated ducts on sono
|
CT/ERCP
|
| Hepatitis A cholestatic type
|
+
|
–
|
N
|
N
|
↑
|
N
|
↑
|
+
|
HAV- AB
|
Abdominal ultrasound
|
| EBV / CMV hepatitis
|
+
|
–
|
N
|
N
|
↑
|
N
|
↑
|
+
|
Positive serology
|
PCR or ELISA
|
| Primary biliary cirrhosis
|
+
|
-/+
|
N/↑
|
N/↑
|
↑
|
N
|
↑
|
–
|
AMA positive
|
Liver biopsy
|
| Primary sclerosing cholangitis
|
+
|
-/+
|
N/↑
|
N/↑
|
↑
|
N
|
↑
|
–
|
Beading on MRCP
|
Liver biopsy
|
| Autoimmune hepatitis
|
Hepatocellular Jaundice
|
-/+
|
-/+
|
↑
|
↑
|
N
|
↑/N
|
N
|
–
|
Anti-LKM antibody
|
Liver biopsy
|
|
