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Kaposi's sarcoma laboratory findings

Introduction

Overview

Overview

Laboratory findings consistent with the diagnosis of Kaposi’s sarcoma include decreased hemoglobin level, positive HIV tests, and positive HHV-8 antigen on immunohistochemistry.

Laboratory Findings

Laboratory Findings

Laboratory findings consistent with the diagnosis of kaposi’s sarcoma include:[1]

Complete blood count

Electrophoresis

  • Detect antibodies against Kaposi sarcoma herpes virus (KSHV) (also known as HHV-8)

ELISA

  • Screens for HIV infection among Kaposi’s sarcoma patients

Western Blot

  • Confirms HIV infection among Kaposi’s sarcoma patients

Immunohistochemistry

  • Kaposi’s sarcoma cells are typically CD34, HHV-8, LANA-1, and D2-40 positive. CD31 and CD34 testing may be useful to assess for vascular origin.
References

References

  1. ↑ Sarcoma- Kaposi Guide. Cancer.Net (2015) http://www.cancer.net/cancer-types/sarcoma-kaposi/risk-factors-and-prevention Accessed on January, 20 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Amandeep Singh M.D.[3]