Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Klebsiella granulomatis
Introduction
This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Donovanosis.
Overview
Overview
Klebsiella granulomatis, originally classified as Calymmatobacterium granulomatis, is a fastidious Gram-negative pleomorphic bacteria causing donovanosis, a gential ulcer disease.
Organism
Organism
- AragĂŁo and Vianna classified the bacteria causing donovanosis as Calymmatobacterium granulomatis in 1913. However, DNA sequencing of 16S rRNA and phoE genes revealed similarity to Klebsiella.[1]
- There is 99% homology between the etiologic agent of donovanosis and members of Klebsiella.[2]
- A proposal has been put forth to reclassify the bacteria to Klebsiella granulomatis.
- K. granulomatis morphology:[3]
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 ÎĽm
- May or may not be capsulated
- Non-motile
Human Pathogen
Human Pathogen
Gallery
Gallery
-
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/b/ba/Granuloma_inguinale12.jpeg)
This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5] -
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/e/ef/Enterobacteria28.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5] -
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/d/da/Enterobacteria56.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5] -
![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/f/f6/Enterobacteria27.jpeg)
Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AGranuloma_inguinale12.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria28.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria56.jpeg)
![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria27.jpeg)
References
References
- ↑ Velho, Paulo Eduardo Neves Ferreira; Souza, Elemir Macedo de; Belda Junior, Walter (2008). “Donovanosis”. Brazilian Journal of Infectious Diseases. 12 (6). doi:10.1590/S1413-86702008000600015. ISSN 1413-8670.
- ↑ Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J; et al. (1997). “Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells”. J Clin Microbiol. 35 (11): 2915–7. PMC 230086. PMID 9350758.
- ↑ Richens J (1991). “The diagnosis and treatment of donovanosis (granuloma inguinale)”. Genitourin Med. 67 (6): 441–52. PMC 1194766. PMID 1774048.
- ↑ O’Farrell N (2002). “Donovanosis”. Sex Transm Infect. 78 (6): 452–7. PMC 1758360. PMID 12473810.
- ↑ 5.0 5.1 5.2 5.3 “Public Health Image Library (PHIL)”.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.;