Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Klinefelter's syndrome natural history, complications and prognosis
Introduction
Overview
Overview
Natural History, Complications and Prognosis
Natural History, Complications and Prognosis
Complications
In these patients, GSTs usually contain nonseminomatous elements, present at an earlier age, and seldom are testicular in location.
The syndrome increases the risk of:
- Attention-deficit hyperactivity disorder
- Autoimmune disorders such as lupus, rheumatoid arthritis, and Sjogren syndrome
- Breast cancer
- Depression
- Dyslexia
- 50 times greater risk of extragonadal germ cell tumor (a rare tumor)[1]
- Learning disabilities, despite normal or high IQ
- Lung disease
- Osteoporosis
- Varicose veins
Enlarged teeth with a thinning surface (taurodontism) is very common in Klinefelter’s syndrome. It can be diagnosed by dental x-rays.
Prognosis
- Most patients have a normal, productive life.
References
References
- ↑ Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome. Gregory G. Bebb, Frederic W. Grannis, Jr, Isaac B. Paz, Marilyn L. Slovak, Robert Chilcote. Ann Thorac Surg 1998;66:547-548. [http://ats.ctsnetjournals.org/cgi/content/abstract/66/2/547 Online}
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]