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Kruppel-associated box gene transcriptions
Introduction
“In rodents and in humans, about one third of the zinc-finger genes carry the Krüppel-associated box (KRAB), a potent repressor of transcription (Margolin et al. 1994), […]. There are more than 200 KRAB-containing zinc-finger genes in the human genome, about 40% of which reside on chromosome 19 and show a clustered organization suggesting an evolutionary history of duplication events (Dehal et al. 2001).”[1]
References
References
- ↑ Deena Schmidt and Rick Durrett (1 December 2004). “Adaptive Evolution Drives the Diversification of Zinc-Finger Binding Domains”. Molecular Biology and Evolution. 21 (12): 2326–2339. doi:10.1093/molbev/msh246. Retrieved 2017-10-16.