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LPHN2

Introduction

Latrophilin 2, also known as LPHN2, is a human gene.[1]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[1]

See also

See also

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: LPHN2 latrophilin 2”.
Further reading

Further reading

  • Südhof TC (2001). “alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins”. Annu. Rev. Neurosci. 24: 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). “The multiple actions of black widow spider toxins and their selective use in neurosecretion studies”. Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
  • Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M; et al. (1999). “Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (5): 277–86. PMID 9872452.
  • White GR, Varley JM, Heighway J (1999). “Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer”. Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
  • White GR, Varley JM, Heighway J (2000). “Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines”. Biochim. Biophys. Acta. 1491 (1–3): 75–92. PMID 10760572.
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED; et al. (2000). “The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins”. J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). “The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
  • Gregory SG, Barlow KF, McLay KE; et al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • Clark TA, Schweitzer AC, Chen TX; et al. (2007). “Discovery of tissue-specific exons using comprehensive human exon microarrays”. Genome Biol. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMID 17456239.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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