LY6G6E

Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene.^[1]

Function

LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction.^[2]

References

↑ “Entrez Gene: Lymphocyte antigen 6 complex, locus G6E pseudogene)”.
↑ Mallya M, Campbell RD, Aguado B (July 2002). “Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms”. Genomics. 80 (1): 113–23. doi:10.1006/geno.2002.6794. PMID 12079290.

Further reading

Mallya M, Campbell RD, Aguado B (October 2006). “Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands”. Protein Science. 15 (10): 2244–56. doi:10.1110/ps.062242606. PMC 2242401. PMID 17008713.
Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (July 1999). “Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region”. Journal of Immunology. 163 (1): 278–87. PMID 10384126.
Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG (January 2009). “Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci”. Arthritis and Rheumatism. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
“Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium”. Nature. 401 (6756): 921–3. October 1999. doi:10.1038/44853. PMID 10553908.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Function