Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
LY75
Introduction
Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.[1][2]
LY75 has also recently been designated CD205 (cluster of differentiation 205). CD205 is also known as DEC-205.
References
References
- ↑ Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). “cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells”. Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150.
- ↑ “Entrez Gene: LY75 lymphocyte antigen 75”.
Further reading
Further reading
- Tungekar MF, Gatter KC, Ritter MA (1996). “Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)”. Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.
- al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). “Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast”. Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.
- McKay PF, Imami N, Johns M, et al. (1999). “The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family”. Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343.
- Palmer DB, Crompton T, Marandi MB, et al. (1999). “Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development”. Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.
- Guo M, Gong S, Maric S, et al. (2000). “A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells”. Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.
- Kato M, Neil TK, Fearnley DB, et al. (2000). “Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells”. Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.
- Kato M, Khan S, Gonzalez N, et al. (2003). “Hodgkin’s lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1”. J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
- Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). “DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes”. Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.
- Nonaka D, Henley JD, Chiriboga L, Yee H (2007). “Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms”. Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270.