Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Latanoprost overdose
Introduction
Overdosage topics
General
Manifestations
Treatment
General
Apart from ocular irritation and conjunctival or episcleral hyperemia, the ocular effects
of latanoprost administered at high doses are not known. Return to top
Manifestations
Intravenous administration of large doses of latanoprost in monkeys has been associated with transient bronchoconstriction; however, in 11 patients with bronchial asthma treated with latanoprost,
bronchoconstriction was not induced. Intravenous infusion of up to 3 μg/kg in healthy volunteers produced mean plasma concentrations 200 times higher than during clinical treatment and no adverse reactions were observed. Intravenous dosages of 5.5 to 10 μg/kg caused abdominal pain, dizziness, fatigue, hot flushes, nausea and sweating. Return to top
Treatment
If overdosage with XALATAN Sterile Ophthalmic Solution occurs, treatment should be
symptomatic.Return to top
Adapted from the FDA Package Insert.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]