Health Dictionary
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Left-right determination factor 1
Introduction
Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. [1]
Function
Function
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
Further reading
Further reading
- Besser D (2004). “Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3”. J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.