Leiomyosarcoma historical perspective

Soft tissue sarcoma derived their name from the greek term for a fleshy lump. Around 460 B.C, Hippocrates recognized soft tissue tumors in the arm and thigh in older people and recommended the removal by knife as therapy. In 200 C.E., a greek physician named Galen suggested that these lumps were cancerous tumors. The exact cause of leiomyosarcoma still is not well understood because of rarety of disease.

• Soft tissue sarcoma derived their name from the Greek term for a fleshy lump.^[1]
• Around 460 B.C, Hippocrates recognized soft tissue tumors in the arm and thigh in older people and recommended the removal by knife as therapy. ^[2]
• Around 200 C.E., a greek physician named Galen suggested that these lumps were cancerous tumors.^[3]
• In 1809, an Edinburg surgeon, Wardrop describes the first illustration of amputation and used the term “soft cancer“.^[4]
• In 1816, Charles Bell, used the term soft tissue sarcoma to differentiate it form carcinoma.^[5]
• In 1804, Abernethy describes the first classification of the sarcoma.^[6]
• In 1932, Stout published a litreature on the pathology and treatment of sarcoma.^[7]
• In 1982, Rosenberg evaluated limb-sparing surgery with adjuvant radiotherapy compared with major amputation.^[8]

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