The majority of patients with leiomyosarcoma remain asymptomatic for decades. General symptoms associated with cancer may occur including fatigue, fever, weight loss, nausea and vomiting, vaginal bleeding, vaginal discharge, feeling of pressure in abdomen or pelvic, painless growing lump in abdomen or pelvic cavity.

The symptoms of leiomyosarcoma depend on the location of the tumor. For the tumors always develop in gastrointestinal tract and uterus, usual symptoms are the following.^{[1][2][3][4][5]}

• Irregular vaginal bleeding (intermenstrual or postmenopausal)

• A new lump or a mass that is protruding into vagina or growing mass in abdomen or pelvis

• Abdominal pain in uterine leiomyosarcoma

• Pelvic pain in uterine leiomyosarcoma
• Dysphagia in esophageal leiomyosarcoma

• Hematemesis in esophageal leiomyosarcoma

• Black, tarry stools or rectal bleeding in rectal leiomyosarcoma

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