Leiomyosarcoma laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]

Overview:

There are no specific laboratory findings associated with leiomyosarcoma, patients may have low hemoglobin and red blood cells on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics.

Lab test:

There are no specific laboratory findings associated with leiomyosarcoma.
Elevated levels of CA-125 and LDH( isozymes) in women with uterine sarcoma, the usefulness of these markers are still being investigated.
There are immunohistochemistry markers associated with sarcoma but it can be positive in any other soft tissue tumors, some of these markers are include:^[1]^[2]^[3]
- Actin and desmin positive.
- Diffusely positive with calponin, h-caldesmon.
- Negative with S100, c-kit and CD34

References

↑ R, Stramare; G, Orsatti (2016). “Imaging Features, Differential Diagnosis and Management of Leiomyosarcomas: Case Series and Review of the Literature”. Journal of Cancer Science & Therapy. 08 (04). doi:10.4172/1948-5956.1000397. ISSN 1948-5956.
↑ Goto A, Takeuchi S, Sugimura K, Maruo T (2002) Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer 12 (4):354-61. PMID: 12144683
↑ Hoskins PJ, Le N (2008) Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 18 (6):1200-1. DOI:10.1111/j.1525-1438.2007.01187.x PMID: 18217961

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[RG2016-1] R, Stramare; G, Orsatti (2016). “Imaging Features, Differential Diagnosis and Management of Leiomyosarcomas: Case Series and Review of the Literature”. Journal of Cancer Science & Therapy. 08 (04). doi:10.4172/1948-5956.1000397. ISSN 1948-5956.

[pmid12144683-2] Goto A, Takeuchi S, Sugimura K, Maruo T (2002) Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer 12 (4):354-61. PMID: 12144683

[pmid18217961-3] Hoskins PJ, Le N (2008) Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 18 (6):1200-1. DOI:10.1111/j.1525-1438.2007.01187.x PMID: 18217961

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Leiomyosarcoma laboratory tests

Overview:

Lab test:

References

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