Leiomyosarcoma surgery
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]
Overview
Overview
Patients with leiomyosarcoma have many treatment options but surgery is considered the mainstay of treatment for all soft tissue sarcomas. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Treatment options are not chosen by the histological subtype of sarcoma but by tumor grade, size, and location of primary or metastatic disease.
Surgery
Surgery
- Surgery is mainstay of therapy in leiomyosarcoma patients, in case of recurrence or progression of disease combination therapy with chemoradiation can be used as well. [1]
- Surgical resection of local recurrence and pulmonary metastases should be considered in individual patients.[2]
- Hysterectomy with bilateral salpingoophorectomy has been the main effective way of surgical therapy in patients with leiomyosarcoma.[3]
- Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.[4][5][6]
| Established stage based on the result of physical exam, imaging and biopsy | |||||||||||||||||||||||||||||||||||||
| Stage 1 low grade tumors | Stage 2 less than 5 cm high grade tumor | Stage 3 more than 5 cm high grade tumor or nodal disease | Stage 4 distant metastasis | ||||||||||||||||||||||||||||||||||
| Surgical resection | surgical resection with or without radiation | surgical resection with radiation with or without chemotherapy | chemotherapy with or without surgical resection | ||||||||||||||||||||||||||||||||||
References
References
- ↑ Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N (2006). “Diagnosis and surgical therapy of uterine sarcoma”. Acta Chir Iugosl. 53 (3): 67–72. PMID 17338203.
- ↑ Grimer, Robert; Judson, Ian; Peake, David; Seddon, Beatrice (2010). “Guidelines for the Management of Soft Tissue Sarcomas”. Sarcoma. 2010: 1–15. doi:10.1155/2010/506182. ISSN 1357-714X.
- ↑ “Treatment for Uterine Sarcoma, by Type and Stage”.
- ↑ Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007. J Cancer Res Clin Oncol 134 (12):1277-87. DOI:10.1007/s00432-008-0422-2 PMID: 18506484
- ↑ Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus. Gynecol Oncol 91 (1):209-12. PMID: 14529683
- ↑ “Uterine Sarcoma Stages”.
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