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Reliable, easy-to-read patient information on common medical conditions โ€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Lentinan

Introduction

Overview

Overview

Lentinan is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake (Lentinula edodes). Lentinan has been approved as an adjuvant for stomach cancer in Japan since 1985.[2] Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.

Chemistry

Chemistry

Lentinan is a ฮฒ-1,3 beta-glucan with ฮฒ-1,6 branching. Molecular weight of lentinan is 500,000 Da. Specific rotation +14-22ยฐ (NaOH).

Research

Research

An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.[1] A pharmacological blend (MC-S) of lentinan, PSK, Ganoderma lucidum and Astragalus propinquus has also been shown to stimulate white blood cell production in vitro.[2]

An in vivo experiment on mice, revealed lentinan is orally active (since clinical use of the drug is administered through an IV).[3]

Limited clinical studies of cancer patients have associated lentinan with a higher survival rate, higher quality of life, and lower re-occurrence of cancer.[4][5][6][7][8][9][10][11]

Formulations containing Lentinan

Formulations containing Lentinan

Lentinex is a formulation featuring lentinan and is approved as a safe novel food in the EU.[12]

References

References

  1. โ†‘ Sia GM, Candlish JK. (Mar 1999). “Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line”. Phytother Res. 13 (2): 133โ€“7. doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O. PMIDย 10190187.
  2. โ†‘ Clark D, Adams M. (2007). “Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support on non-stimulated human lymphocytes”. Austr. J. Med. Herbal. 19: 108โ€“111.
  3. โ†‘ Ng ML, Yap AT. (Oct 2002). “Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)”. J Altern Complement Med. National University of Singapore. 8 (5): 581โ€“9. doi:10.1089/107555302320825093. PMIDย 12470439.
  4. โ†‘ Yang P, Liang M, Zhang Y, Shen B. (Aug 2008). “Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC”. Adv Ther. 25 (8): 787โ€“94. doi:10.1007/s12325-008-0079-x. PMIDย 18670743.
  5. โ†‘ Nimura H, Mitsumori N, Takahashi N, (Jun 2006). “[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]”. Gan to Kagaku Ryoho. 33 (1): 106โ€“9. PMIDย 16897983.
  6. โ†‘ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999). “A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group”. Hepatogastroenterology. 46 (28): 2662โ€“8. PMIDย 10522061.
  7. โ†‘ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). “Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer”. Anticancer Res. 29 (7): 2739โ€“45. PMIDย 19596954.
  8. โ†‘ Hazama S, Watanabe S, Ohashi M; et al. (July 2009). “Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer”. Anticancer Res. 29 (7): 2611โ€“7. PMIDย 19596936.
  9. โ†‘ Kataoka H, Shimura T, Mizoshita T; et al. (2009). “Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life”. Hepatogastroenterology. 56 (90): 547โ€“50. PMIDย 19579640.
  10. โ†‘ Isoda N, Eguchi Y, Nukaya H; et al. (2009). “Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma”. Hepatogastroenterology. 56 (90): 437โ€“41. PMIDย 19579616.
  11. โ†‘ Shimizu K, Watanabe S, Watanabe S; et al. (2009). “Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer”. Hepatogastroenterology. 56 (89): 240โ€“4. PMIDย 19453066.
  12. โ†‘ EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). European Food Safety Authority (EFSA), Parma, Italy (2010), “Scientific Opinion on the safety of “Lentinus edodes extract” (Lentinexยฎ) as a Novel Food ingredient” (PDF), EFSA Journal, 7 (8): 1685, doi:10.2903/j.efsa.2010.1685

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]