Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Linitis plastica causes
Introduction
Overview
Overview
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.
Causes
Causes
Primary Causes
- Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.[1]
- Somatic mutations in the CDH1 gene can occur by:
- Hypermethylation
- Loss of heterozygosity
- Silencing mutations
Secondary causes
- Lye ingestion
- Metastatic infiltration of the stomach by:
References
References
- ↑ Graziano F, Humar B, Guilford P (2003). “The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice”. Ann. Oncol. 14 (12): 1705–13. PMID 14630673.
- ↑ Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC (1996). “Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica”. Radiology. 201 (2): 375–8. doi:10.1148/radiology.201.2.8888226. PMID 8888226.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]