Linitis plastica natural history

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach that may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.^[1]^[2] Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.^[2]

Natural history

Patients are usually asymptomatic in the initial stages of the disease. If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach and may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.^[1]^[2]

Complications

Patients with linitis plastica may progress to develop gastric outlet obstruction from the rigid stomach wall that limits the process of digestion.^[3]

Prognosis

Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica because of the rapid peritoneal and lymphatic spread of the disease. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.^[2]

References

↑ ^1.0 ^1.1 Jafferbhoy S, Shiwani H, Rustum Q (2013). “Managing Gastric Linitis Plastica: Keep the scalpel sheathed”. Sultan Qaboos Univ Med J. 13 (3): 451–3. PMC 3749031. PMID 23984032.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.
↑ Shiver SA, Blaivas M (2004). “Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography”. J Ultrasound Med. 23 (7): 989–92. PMID 15292571.

Template:WikiDoc Sources

[pmid23984032-1] 1.0 ^1.1 Jafferbhoy S, Shiwani H, Rustum Q (2013). “Managing Gastric Linitis Plastica: Keep the scalpel sheathed”. Sultan Qaboos Univ Med J. 13 (3): 451–3. PMC 3749031. PMID 23984032.

[og-2] 2.0 ^2.1 ^2.2 ^2.3 Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.

[pmid15292571-3] Shiver SA, Blaivas M (2004). “Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography”. J Ultrasound Med. 23 (7): 989–92. PMID 15292571.

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