Liposarcoma historical perspective

Liposarcoma was first described by Rudolph Virchow, a German pathologist, in 1857. Virchow reported a “myxoma lipomatoides malignum”, highlighting the malignant nature of the tumor. Between 1954 and 1979, several authors reported cases of liposarcoma and suggested that liposarcoma should be classified according to histopathological analysis into well-differentiated, myxoid, and dedifferentiated subtypes.

• Liposarcoma was first discovered in 1857 by Rudolph Virchow, a German pathologist, who described a tumor arising from fat tissue. Originally, Virchow called the tumor “myxoma lipomatodes malignum”.^[1]
• Virchow demonstrated that the tumor has a malignant nature.
• In 1859, Delamater reported a “mammoth” retroperitoneal tumor with lipomatous aspect.^[2]

• Several lesions similar to lipoma myxomatodes were reported by Robertson in 1916.^[3]
• In 1921, Von Wahlendorf demonstrated that retroperitoneal tumors of the adipose tissue that are dangerous in a collective review of liposarcomas (14%) of 168 collected cases.^[4]
• The malignant component of the liposarcoma was described in 1927 by Seids et al., who reported malignant lesions with a myxoid component.^[5]
• Ewing described adipose tumors that arise from the embryonal tissue in adults in 1935.^[6]
• In 1942 and 1944, liposarcoma was described in different anatomical locations and with different clinical manifestations that were associated with the disease prognosis. ^[7][8]
• Between 1954 and 1979, several authors reported cases of liposarcoma and suggested that liposarcoma should be classified according to histopathological analysis into well-differentiarted, myxoid, and dedifferentiated subtypes. ^[9][10][11]

• In 2014, Rob Ford, the mayor of Toronto, was diagnosed with an abdominal pleomorphic liposarcoma.

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