Liposarcoma history and symptoms

Liposarcoma usually presents as a painless mass. The most common location of a liposarcoma is the lower extremities. Patients with retroperitoneal liposarcoma remain asymptomatic until the mass invades adjacent structures, which may cause pain or obstructive symptoms. Esophageal liposarcoma may cause dysphagia, vomiting, cough, gastrointestinal bleeding, and hoarseness. Symptoms of gastrointestinal bleeding are common manifestations of liposarcoma located in the small bowel and the colon. Symptoms of mediastinal liposarcoma include dyspnea, cough, chest pain, and weight loss.

• Symptoms of liposarcoma will depend on the location of the tumor.
• Liposarcoma located in the deep soft tissue of the extremities presents as a painless mass that grows slowly over several months.
• Superficial liposarcomas are commonly located in the lower extremities, especially in the femoral and popliteal regions.

• The majority of patients with retroperitoneal liposarcoma remain asymptomatic until the tumor grows to a considerable size (10 – 20 cm).
• Common symptoms of retroperitoneal liposarcoma include weight loss and abdominal pain.^[1]
• The tumor may compress adjacent organs and vascular structures to cause pain or obstructive symptoms.^[2]
• The kidneys or ureters may also be involved, which may result in urologic symptoms, such as oliguria, or renal failure.

• Esophageal liposarcoma is extremely rare.^[3]
• Esophageal liposarcoma may cause difficulty swallowing, vomiting, cough, gastrointestinal bleeding, and hoarseness.^[3]

• Symptoms of gastrointestinal bleeding are common manifestations of liposarcoma located in the small bowel and the colon.^[4]

• Mediastinal liposarcomas are rare.
• Symptoms include difficulty breathing, cough, chest pain, and weight loss.^[5][6]
• Difficulty swallowing^[6]

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