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List of chemotherapeutic agents
Introduction
Overview
Overview
This is a list of chemotherapeutic agents that are known to be of use in chemotherapy for cancer. A full alphabetical listing is included after the categorical listing.
The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy).
Chemotherapeutic Agents by Category
Chemotherapeutic Agents by Category
Alkylating agents
Nitrogen mustards
- Chlorambucil (Leukeran)
- Cyclophosphamide (Cytoxan)
- Estramustine (Emcyt)
- Ifosfamide (Iflex)
- Melphalan (Alkeran)
- Mechlorethamine (Mustargen)
Ethylenimines
Methylhydrazines
Alkylsulfonates
Nitrosoureas
Triazenes
Platinum coordination complexes
Antimetabolites
Folic acid analogs
Pyrimidine analogs
- Azacytidine (Vidaza)
- Capecitabine (Xeloda)
- Cytarabine (Cytosar)
- Decitabine (Dacogen)
- Floxuridine (FUDR)
- Fluorouracil (Adrucil, Efudex)
- Gemcitabine (Gemzar)
- Raltitrexed (Tomudex)
Purine analogs
- Cladribine (Leustatin)
- Clofarabine (Clolar)
- Fludarabine (Fludara)
- Mercaptopurine (Purinethol)
- Nelarabine (Arranon)
- Pentostatin (Nipent)
- Thioguanine (Tabloid)
Ribonucleotide reductase inhibitors
Natural products
Vinca alkaloids
- Vinblastine (Velban, Velsar)
- Vincristine (Oncovin, Vincasar)
- Vincristine liposome (Marqibo)
- Vinflunine (Javlor)
- Vinorelbine (Navelbine)
Taxanes
Epipodophyllotoxins
Camptothecins
Antineoplastic antibiotics
- Bleomycin (Blenoxane)
- Dactinomycin (Cosmegen)
- Daunorubicin (Cerubidine)
- Daunorubicin liposome (Daunoxome)
- Doxorubicin (Adriamycin, Rubex)
- Epirubicin (Ellence)
- Idarubicin (Idamycin)
- Mitomycin C (Mutamycin)
- Mitoxantrone (Novantrone)
- Pixantrone (Pixuvri)
- Plicamycin (Mithracin)
- Valrubicin (Valstar)
Antineoplastic enzymes
Hormones and Antagonists
Adrenocortical suppressants
Glucocorticoids
Progestins
Estrogens
Anti-estrogens
Aromatase inhibitors
Androgens
Anti-androgens
- Abarelix (Plenaxis)
- Abiraterone (Zytiga)
- Bicalutamide (Casodex)
- Enzalutamide (Xtandi)
- Flutamide (Eulexin)
- Nilutamide (Nilandron)
LHRH agonists
GnRH agonists
GnRH antagonists
Biologics
Monoclonal antibodies
Anti-CD3 antibodies
Anti-CD3 & anti-CD19 antibodies
Anti-CD20 antibodies
- Rituximab (Rituxan)
- Ibritumomab tiuxetan (Zevalin))
- Obinutuzumab (Gazyva)
- Ofatumumab (Arzerra)
- Tositumomab (Bexxar)
Anti-CD30 antibodies
Anti-CD33 antibodies
Anti-CD52 antibodies
Anti-CTLA–4 antibodies
Anti-EGFR (ErbB1) antibodies
Anti-PD–1 antibodies
Anti-HER2/neu (ErbB2) antibodies
Anti-VEGF antibodies
IL-6 inhibitors
Immunotherapy
- Aldesleukin (Proleukin)
- Denileukin diftitox (Ontak)
- Interferon alfa-2b (Intron A)
- Peginterferon alfa-2a (Pegasys)
- Peginterferon alfa-2b (Sylatron)
Hematopoietic Growth Factors
Erythrocyte growth factors
Granulocyte growth factors
- Filgrastim (Neupogen)
- Pegfilgrastim (Neulasta)
- Plerixafor (Mozobil)
- Sargramostin (Leukine, Leukomax)
- Tbo-filgrastim (Granix)
Megakaryocyte growth factors
Supportive Medications
Chemotherapy protective agents
- Amifostine (Ethyol)
- Cyanocobalamin (Cobal)
- Dexrazoxane (Zinecard)
- Folinic acid (Leucovorin Calcium)
- Glucarpidase (Voraxaze)
- Levoleucovorin (Fusilev)
- Mesna (Mesnex)
- Rasburicase (Elitek)
Antiemetic agents
RANK ligand inhibitors
Calcium regulators
Miscellaneous
Mitotic inhibitors
HDAC inhibitors
Hedgehog pathway inhibitors
Immunomodulatory drugs (IMiDs)
Kinase inhibitors
- Afatinib (Gliotrif)
- Axitinib (Inlyta)
- Bosutinib (Bosulif)
- Cabozantinib (Cometriq)
- Ceritinib (Zykadia)
- Crizotinib (Xalkori)
- Dabrafenib (Tafinlar)
- Dasatinib (Sprycel)
- Erlotinib (Tarceva)
- Everolimus (Afinitor)
- Gefitinib (Iressa)
- Ibrutinib (Imbruvica)
- Idelalisib (Zydelig)
- Imatinib (Gleevec)
- Lapatinib (Tykerb)
- Lenvatinib (Lenvima)
- Nilotinib (Tasigna)
- Palbociclib (Ibrance)
- Regorafenib (Stivarga)
- Ruxolitinib (Jakafi)
- Sorafenib (Nexavar)
- Sunitinib (Sutent)
- Temsirolimus (Torisel)
- Trametinib (Mekinist)
- Vandetanib (Caprelsa)
- Vemurafenib (Zelboraf)
- Ziv-aflibercept (Zaltrap)
Photosensitizing agents
Proteasome inhibitors
Radioactive agents
Somatostatin analogs
Differentiating agents
Orphan drugs
Chemotherapeutic Agents in Alphabetical Order
Chemotherapeutic Agents in Alphabetical Order
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3Editor-In-Chief: Template:Seealso C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]; Steven Bellm, M.D. [3]