Loa loa filariasis historical perspective

The first case of Loa loa infection was noted in the Caribbean (Santo Domingo) in 1770. Localized angioedema, a common clinical presentation of loiasis, was observed in 1895 in the coastal Nigerian town of Calabar—hence the name, Calabar swellings. The association between Loa loa and Calabar swellings was not realized until 1910 (by Dr. Patrick Manson).

The first case of Loa loa infection was noted in the Caribbean (Santo Domingo) in 1770. A French surgeon named Mongin tried but failed to remove a worm passing across a woman’s eye. A few years later, in 1778, the surgeon François Guyot noted worms in the eyes of West African slaves on a French ship to America; he successfully removed a worm from one man’s eye. The first case of Loa loa infection was noted in the Caribbean (Santo Domingo) in 1770. Localized angioedema, a common clinical presentation of loiasis, was observed in 1895 in the coastal Nigerian town of Calabar—hence the name, Calabar swellings. This observation was made by a Scottish ophthalmologist named Douglas Argyll-Robertson, but the association between Loa loa and Calabar swellings was not realized until 1910 (by Dr. Patrick Manson). The determination of vector—Chrysops spp.—was made in 1912 by the British parasitologist Robert Thomson Leiper.^[1]

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