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MARC1
Introduction
Mitochondrial amidoxime-reducing component 1 (also known as MOCO sulphurase C-terminal domain containing 1, MOSC1 or MARC1) is an enzyme which in humans is encoded by the MOSC1 gene.[1]
Moco stands for molybdenum cofactor.
MOSC1 has been reported to reduce amidoximes to amidines.[2][3]
References
References
- ↑ Anantharaman V, Aravind L (January 2002). “MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases”. FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
- ↑ Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (November 2006). “Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme”. J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.
- ↑ Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (December 2008). “The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs”. J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.