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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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MDGA2

Introduction

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]

There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]

References

  1. ↑ “MDGA2 Gene — GeneCards”. Weizmann Institute of Science. 2008-09-08.
  2. ↑ “Rat Genome Database: Mdga2 ( Rattus norvegicus )”. Medical College of Wisconsin. Retrieved 2008-11-14.
  3. ↑ Litwack ED, Babey R, Buser R, Gesemann M, O’Leary DD (February 2004). “Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization”. Molecular and Cellular Neuroscience. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943.
  4. ↑ “SNP linked to Gene MDGA2”. NCBI.
  5. ↑ van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). “18762592”. Archives of General Psychiatry. 65 (9): 1062&ndash, 1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
  6. ↑ Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning. “Follow-up association study of novel neuroticism gene MAMDC1”. Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892.